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文獻名： Evaluation of the cytotoxicity of gold nanoparticle-quercetin complex and its potential as a drug delivery vesicle
作者： Pyo June Pak, , Eun Byeol Go, , Min Hee Hwang, Dong Gun Lee, Mi Ju Cho, Yong Hoon Joo, Namhyun Chung,
Department of Biosystems Engineering, College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of Korea
摘要：Recently, conjugates of medicinal herb-derived bio-flavonoids, such as quercetin, and gold nanoparticles (GNPs) have gained attention as targeted drug delivery systems. In the present study, because quercetin is an important flavonoid with anti-cancer, anti-inflammatory, and anti-oxidant properties, GNP-quercetin complexes (GNPQs) were synthesized to investigate possible adverse effects such as cytotoxicity. We found that while quercetin was cytotoxic, GNPQs were not cytotoxic towards the RAW 264.7 and THP-1 cell lines. Therefore, GNPQs may serve as a potential drug delivery system for cancer treatment.
關(guān)鍵詞：Citrate synthesis, Drug delivery system, Gold nanoparticle, Quercetin
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